Groups working in the areas of
- Microscopy
- Biophotonical Receptor Research
- Ophthalmology
- Imaging
- Biomedical Laser Applications
- Miscelleanous
Microscopy
Experimental Neurology, BioImaging group
2-photon microscopy, single cell electrophysiology, synaptic plasticity,
neuronal network activity, calcium, dendrite, spine
Institute of Physical Chemistry;
IPHT Jena: Dept. Microscopy and Dept. Spectroscopy/Imaging
molecular imaging, raman microscopy, biophotonics, high resolution
microscopy, nanobiophotonics, fluorescence microscopy, confocal
microscopy, imaging, image processing
AG Biomolecular Photonics
fluorescence lifetime imaging, FRET measurements,
Protein-protein interaction measurements in living cells,
nanosensors, automated image analysis, patch-clamp fluorometry
Research Group Cell Biology of the Cytoskeleton
molecular mechanisms of actin dynamics; cytoskeletal functions of cell
differentiation & reorganization; neuronal morphogenesis & plasticity;
modern methods in molecular biology, genetics, biophysics, biochemistry,
cell and developmental biology.
Experimental Nephrology - Systems Biology
Systems Biology, Computational and Experimental Analysis Gene
Regulation, Protein-Protein Interactions, Gene-Expression Data, DNA-
sequences, Transcription Factor Binding Sites, miRNA function, drug based
iPS, optical methods to study gene regulation
Single-Molecule Microscopy Group
analysis of single FoF1-ATP synthases and transporters by multi
dimensional confocal microscopy (FRET, FLIM), fluorescence correlation
spectroscopy (FCS, FCCS), ABELtrap, single-molecule based imaging
(PALM, STORM, FRAP)
Biophotonical Receptor Research
CMB, Department of Biophysics
ion channels, neurotoxins, and molecular mechanisms of cellular regulation
microscopic photonic methods to measure cellular parameters as well as
to specifically manipulate cell functions
Neuroimmunology and Synaptopathy
autoimmunity against neuronal membrane receptors; autoantibodies;
autoimmune encephalitis; synaptic remodeling; super-resolution
microscopy; dSTORM; cellular electrophysiology; synaptic plasticity;
animal models; septic encephalopathy
Institute of Physiology II
characterization of the structure-function relation of ion channels: CNG
channels, HCN pacemaker channels, and cardiac ion channels
molecular biological, electrophysiological, optical and mathematical
methods confocal Patch-Clamp Fluorometry
Institute for Biochemistry I
innovative fluorescent tools in cell biology at high resolution and dynamics;
tracking of proteins & membranes; actin dynamics and membrane
modulation in morphogenesis & membrane trafficking; neuronal structure,
function & plasticity
Ophthalmology
Experimental Ophthalmology
new methods for objective detection of early metabolic alterations of the
eye: in vivo fluorescence lifetime imaging, oxygen saturation in retinal
vessels, density of macular pigment, 2-photon studies on organ cultures
Institute for Applied Optics, Ophthalmology Group
measurement and correction of aberrations of the human eye using an
adaptive real-time phoropter, studying the influence of higher order
aberrations on vision (visus, contrast, glare sensitivity)
Imaging
Working group oncology, ENT department
improving the detection of head and neck cancer and its tumor margins
with confocal mini-endoscopy and RAMAN spectroscopy in correlation to
histopathology and proteomic analyses
Medical Physics Group
tomographic biomedical and clinical imaging, in particular MRI: Diffusion
Tensor Imaging (DTI), MR Spectroscopy, MR Mammography, small animal
MRI, Susceptibility weighted Imaging, Phase Imaging, Phase Unwrapping
Chair of Nonlinear Optics
X-ray Coherence Tomography, Generation of short-wavelength radiation,
Laser Radiation Therapy
Biomagnetic Centre
We explore cortical processing following visual perception of stimuli using
Magnetic Source Imaging. The technology is based on a completely non-
invasive procedure involving picking up and measuring the biomagnetic
field generated by cortical neurons.
Working Group Neuroimaging
investigates the function of the human brain by functional imaging, direct
visualization of various interactions within the somatosensory system, and
the development of customised therapies for a variety of neurological
diseases such as stroke and chronic pain.
Structural Brain Mapping Group
methods for structural brain imaging, Schizophrenia research,
gyrification and cortical measures, surface shape analysis, classification
of brain structure, early detection of Schizophrenia and Alzheimer's Disease
Working Group Fiber Anatomy, Department of Neurology
Central nervous fiber architecture, human connectome, connectivity,
polarized light imaging (PLI), diffusion tensor MRI, Wallerian degeneration
after cns lesion.
Core Unit Chip Application
Laser-based tissue microdissection, chip technologies and molecular
imaging techniques are used for the analysis of tumor heterogeneity and
for the identification of biomarkers to enable an early enough diagnosis.
Working group: Experimental Radiology
In vivo imaging of pathomolecular mechanisms in relation to Morbus
Alzheimer disease, breast cancer and inflammation using UWB, MRI and
optical techniques. Design of minimal-invasive techniques for the treatment
of tumours and inflammatory diseases.
Biomedical Laser Applications
POLARIS/ultra photonics
The group uses high-intensity laser pulses to generate particle and
radiation pulses of high energy. This radiation is further characterized, e.g.
in terms of the biological effectiveness for cell irradiation.
Miscelleanous
IPHT Jena, Nanoscopy
Spectroscopy on the Nanoscale, instrumental developments for sub
wavelength spatial resolution, structural investigation of single prions,
viruses etc., structure-dynamic relation of single proteins in lipid
membranes
Experimental Anesthesiology
fluorescence microscopy, NIR, molecular mechanisms of cellular
dysfunction in shock and sepsis related organ failure (redox status,
transcellular transport, excretory dysfunction)
Organic and Macromolecular Chemistry
tailor-made functional polymers, nanoparticles and nanocontainers,
luminescent metal complexes, metal-based supramolecular polymers,
responsive materials, high-throughput experimentation
Supramolecular Analytical Chemistry
Boronic acid-rezeptors for sugars, Fluorescent enzyme assays,
Photoswitchable receptors, molecular logic in sugar diagnostics
Fluorescence correlation spectroscopy (FCS), confocal
microscopy
Chair of Materials Science
Microscopy and spectroscopy of materials (polymers, ceramics, metals,
composites): REM-FIB, CLSM, TEM, AFM, raman microscopy, µCT imaging,
nanoindentation, ellipsometry, UV-Vis, XPS, LED photopolymerization,
materials science
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